Me ka makahiki, peptide poho, koko moku paia elasticity deteriorates, e pili ana i ka paʻa o ke koko, viscosity koko, maʻalahi ke kumu o ka momona ate, hyperlipidemia, cerebral thrombosis, a me ka hoʻomanaʻo emi, dizziness, poina, insomnia.ʻO ka nalowale o nā peptides hiki ke alakaʻi i ka emi ʻana o ka nui o ka iwi, ka hoʻokumu ʻana o nā lua, a me ka nalowale o ka calcium, e hoʻoulu ai i ka iwi a me ka ʻeha hui, nā iwi iwi, nā wāwae a me nā wāwae hiki ʻole, osteoporosis, maʻalahi ka haʻihaʻi, hoʻōla iwi lohi, a hoʻemi i ka paʻakikī o ka iwi.